Pinhead is stuck in a block after the Big Confrontation in "Hellbound," The block containing Pinhead and the puzzle cube is bought by a young playboy as sculpture. Pinhead busies himself escaping by getting the playboy to lure victims to his presence so he can use their blood. Once free, he seeks to destroy the puzzle cube so he need never return to Hell, but a female reporter is investigating the grisly murders and stands in his way.

When Detective Rebecca Madsen is assigned to a grisly homicide case, a fingerprint leads her to a shocking suspect: Jack Sylvane, a former Alcatraz inmate who died decades ago. With her investigation impeded by government agent Emerson Hauser, Madsen teams up with Alcatraz expert and comic book enthusiast Dr. Diego Soto. They both soon discover that Sylvane is not only alive, but he’s loose on the streets of San Francisco, leaving bodies in his wake, and does not appear to age. With the inclusion of Agent Hauser, they realize that Sylvane is only a small part of a much larger, more sinister present-day threat. For while he may be the first, it quickly becomes clear that Sylvane won’t be the last prisoner to reappear from Alcatraz.

Some say that all houses have memories. For one man, his home is the place he would kill to forget. A family unknowingly moves into a home where several grisly murders were committed...only to find themselves the killer s next target. Successful publisher Will Atenton (Craig) quit a job in New York City to relocate his wife, Libby (Weisz), and two girls to a quaint New England town. But as they settle into their new life, they discover their perfect home was the murder scene of a mother and her children. And the entire city believes it was at the hands of the husband who survived. When Will investigates the tragedy, his only lead comes from Ann Paterson (Watts), a neighbor who was close to the family that died. As Will and Ann piece together the disturbing puzzle, they discover that the story of the last man to leave Will s dream house will be just as horrifying to the one who came next.